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Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane.

Abstract:

Rap1 is a small GTPase that modulates adhesion of T cells by regulating inside-out signaling through LFA-1. The bulk of Rap1 is expressed in a GDP-bound state on intracellular vesicles. Exocytosis of these vesicles delivers Rap1 to the plasma membrane, where it becomes activated. We report here that phospholipase D1 (PLD1) is expressed on the same vesicular compartment in T cells as Rap1 and is translocated to the plasma membrane along with Rap1. Moreover, PLD activity is required for both tr...

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Publisher copy:
10.1128/mcb.00366-09

Authors


Ahearn, IM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Molecular and cellular biology
Volume:
29
Issue:
12
Pages:
3297-3306
Publication date:
2009-06-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:d7e6f048-938e-48cf-88ef-cd239dc917e7
Source identifiers:
426302
Local pid:
pubs:426302

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