Journal article icon

Journal article

Antibody inhibiting enzymatic activity of tumour-associated carbonic anhydrase isoform IX.

Abstract:

Carbonic anhydrase IX (CAIX) is a hypoxia-induced, membrane-tethered enzyme that is highly expressed in many cancers. It catalyses the hydration of CO(2) to HCO(3)(-) and H(+), and the reverse dehydration reaction. Recent studies have shown an important role for CAIX in pH regulation and it has been speculated that CAIX may play a role in supporting cancer progression towards more aggressive forms of the disease. Clinical correlative studies in many tumours have shown that high expression is ...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Murri-Plesko, MT More by this author
Hulikova, A More by this author
Oosterwijk, E More by this author
Expand authors...
Journal:
European journal of pharmacology
Volume:
657
Issue:
1-3
Pages:
173-183
Publication date:
2011-04-05
DOI:
EISSN:
1879-0712
ISSN:
0014-2999
URN:
uuid:d7cacb09-fd06-4d19-a593-728922fcfe98
Source identifiers:
118059
Local pid:
pubs:118059

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP