Antibody inhibiting enzymatic activity of tumour-associated carbonic anhydrase isoform IX.

Journal article

Carbonic anhydrase IX (CAIX) is a hypoxia-induced, membrane-tethered enzyme that is highly expressed in many cancers. It catalyses the hydration of CO(2) to HCO(3)(-) and H(+), and the reverse dehydration reaction. Recent studies have shown an important role for CAIX in pH regulation and it has been speculated that CAIX may play a role in supporting cancer progression towards more aggressive forms of the disease. Clinical correlative studies in many tumours have shown that high expression is ...

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Authors: Murri-Plesko, M; Hulikova, A; Oosterwijk, E; Scott, A; Zortea, A

• Publication status: Published
• Journal: European journal of pharmacology
• Volume: 657
• Issue: 1-3
• Pages: 173-183
• Publication date: 2011-04-01
• DOI: 10.1016/j.ejphar.2011.01.063
• EISSN: 1879-0712
• ISSN: 0014-2999
• Language: English
• Keywords: Carbonic Anhydrase Inhibitors; Immunoglobulin Fragments; Carbonic Anhydrases; Cell Membrane; Peptide Library; Gene Expression Regulation, Neoplastic; Cell Line, Tumor; Spheroids, Cellular; Neoplasms; Antigens, Neoplasm; Antibody Specificity; Animals; Humans