Increasing inflationary T-cell responses following transient depletion of MCMV-specific memory T cells

Journal article

Murine CMV (MCMV) infection induces effector CD8+ T cells that continue to increase in frequency after acute infection (“inflation”) and are stably maintained at a high frequency, with up to 20% of the CD8+ T-cell compartment being specific for one epitope, although the flexibility and turnover of these populations is not fully defined. Here we report that effector/memory CD8+ T cells induced by MCMV can be paradoxically boosted following transient depletion of epitope specific CD8+ T cells. Treatment of MCMV-infected mice with MHC-Class I-saporin tetramers led to partial (80–90%) depletion of epitope-specific CD8+ T cells—rapidly followed by a rebound, leading to expansion and maintenance of up to 40% of total CD8+ T cells, with minimal changes in response to a control epitope (M45). These data indicate the tight balance between host and virus during persistent infection and the functional flexibility of the “inflated” CD8+ T cell responses during persistent infection.

Authors: Sims, S; Klenerman, P; Bolinger, B

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Wiley
• Journal: European Journal of Immunology
• Volume: 45
• Issue: 1
• Pages: 113-118
• Publication date: 2015-01-01
• DOI: 10.1002/eji.201445016
• EISSN: 1521-4141
• ISSN: 0014-2980
• Keywords: MCMV; memory T cells; inflationary T-cell response