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Increasing inflationary T-cell responses following transient depletion of MCMV-specific memory T cells

Abstract:

Murine CMV (MCMV) infection induces effector CD8+ T cells that continue to increase in frequency after acute infection (“inflation”) and are stably maintained at a high frequency, with up to 20% of the CD8+ T-cell compartment being specific for one epitope, although the flexibility and turnover of these populations is not fully defined. Here we report that effector/memory CD8+ T cells induced by MCMV can be paradoxically boosted following transient depletion of epitope specific CD8+ T cells. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/eji.201445016

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Bolinger, B More by this author
Publisher:
Wiley-VCH Verlag Publisher's website
Journal:
European Journal of Immunology Journal website
Volume:
45
Issue:
1
Pages:
113-118
Publication date:
2015-01-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:d7afe6ff-af16-4029-8137-230e15e0eb71
Source identifiers:
505980
Local pid:
pubs:505980

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