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Hypoxia and HIF pathway in cancer and the placenta

Abstract:

In this review we note that the placenta and cancer both develop in microenvironments in which there are gradients of oxygen availability. Whilst fundamentally different in that placental development is organised and physiological whilst cancer is chaotic and pathological, there are similarities in their respective capacities to proliferate, invade adjacent tissues, generate a blood supply and avoid rejection by the immune system. We provide a brief description of the hypoxia-inducible factor...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1016/j.placenta.2017.03.010

Authors


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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
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Department:
Oxford, MSD, NDM, NDM Experimental Medicine
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Department:
Kellogg College
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Department:
Oxford, MSD, NDM, Oxford Ludwig Institute
Pathological Society of Great Britain and Ireland More from this funder
Jean Shanks Foundation More from this funder
Wellcome Trust More from this funder
Medical Research Council More from this funder
British Heart Foundation More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Placenta Journal website
Volume:
56
Pages:
8-13
Publication date:
2017-03-13
Acceptance date:
2017-03-14
DOI:
EISSN:
1532-3102
ISSN:
0143-4004
Pubs id:
pubs:687814
URN:
uri:d7af423f-3579-42ea-91d2-94d4b396578e
UUID:
uuid:d7af423f-3579-42ea-91d2-94d4b396578e
Local pid:
pubs:687814

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