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Journal article

Hypoxia and HIF pathway in cancer and the placenta

Abstract:

In this review we note that the placenta and cancer both develop in microenvironments in which there are gradients of oxygen availability. Whilst fundamentally different in that placental development is organised and physiological whilst cancer is chaotic and pathological, there are similarities in their respective capacities to proliferate, invade adjacent tissues, generate a blood supply and avoid rejection by the immune system. We provide a brief description of the hypoxia-inducible factor...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.placenta.2017.03.010

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Societies, Other & Subsidiary Companies
Department:
Kellogg College
Oxford college:
Kellogg College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
Ludwig Institute for Cancer Research More from this funder
National Institute for Health Research More from this funder
Oak Foundation More from this funder
Cancer Research UK More from this funder
British Heart Foundation More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Placenta Journal website
Volume:
56
Pages:
8-13
Publication date:
2017-03-01
Acceptance date:
2017-03-14
DOI:
EISSN:
1532-3102
ISSN:
0143-4004
Source identifiers:
687814
Language:
English
Keywords:
Pubs id:
pubs:687814
UUID:
uuid:d7af423f-3579-42ea-91d2-94d4b396578e
Local pid:
pubs:687814
Deposit date:
2017-04-13

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