Journal article
Altered tumor formation and evolutionary selection of genetic variants in the human MDM4 oncogene.
- Abstract:
-
A large body of evidence strongly suggests that the p53 tumor suppressor pathway is central in reducing cancer frequency in vertebrates. The protein product of the haploinsufficient mouse double minute 2 (MDM2) oncogene binds to and inhibits the p53 protein. Recent studies of human genetic variants in p53 and MDM2 have shown that single nucleotide polymorphisms (SNPs) can affect p53 signaling, confer cancer risk, and suggest that the pathway is under evolutionary selective pressure (1-4). In ...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America More from this journal
- Volume:
- 106
- Issue:
- 25
- Pages:
- 10236-10241
- Publication date:
- 2009-06-01
- DOI:
- EISSN:
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1091-6490
- ISSN:
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0027-8424
Item Description
- Language:
-
English
- Keywords:
- UUID:
-
uuid:d7a3e056-e338-44b8-9a38-fbb92f8e0939
- Local pid:
-
pubs:69619
- Source identifiers:
-
69619
- Deposit date:
-
2012-12-19
Terms of use
- Copyright date:
- 2009
- Notes:
- Note: an erratum exists for this article, originally published and available at: https://doi.org/10.1073/pnas.0901298106
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