Journal article icon

Journal article

Multiple renal cancer susceptibility polymorphisms modulate the HIF pathway.

Abstract:

Un-physiological activation of hypoxia inducible factor (HIF) is an early event in most renal cell cancers (RCC) following inactivation of the von Hippel-Lindau tumor suppressor. Despite intense study, how this impinges on cancer development is incompletely understood. To test for the impact of genetic signals on this pathway, we aligned human RCC-susceptibility polymorphisms with genome-wide assays of HIF-binding and observed highly significant overlap. Allele-specific assays of HIF binding,...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pgen.1006872

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM
Role:
Author
Expand authors...
More from this funder
Grant:
088182/Z/09/Z, 078333/Z/05/Z, WT091857MA
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
13
Issue:
7
Pages:
e1006872
Publication date:
2017-07-17
Acceptance date:
2017-06-15
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Pubs id:
pubs:709433
URN:
uri:d7858f4a-baa1-4b8f-8476-8dce1c67a264
UUID:
uuid:d7858f4a-baa1-4b8f-8476-8dce1c67a264
Local pid:
pubs:709433
Paper number:
7

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP