Journal article icon

Journal article

Astrocyte-secreted glypican 4 regulates release of neuronal pentraxin 1 from axons to induce functional synapse formation

Abstract:

The generation of precise synaptic connections between developing neurons is critical to the formation of functional neural circuits. Astrocyte-secreted glypican 4 induces formation of active excitatory synapses by recruiting AMPA glutamate receptors to the postsynaptic cell surface. We now identify the molecular mechanism of how glypican 4 exerts its effect. Glypican 4 induces release of the AMPA receptor clustering factor neuronal pentraxin 1 from presynaptic terminals by signaling through ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

Actions


Access Document


Files:
Publisher copy:
10.1016/j.neuron.2017.09.053

Authors


Farhy-Tselnicker, I More by this author
More by this author
ORCID:
0000-0002-6543-7399
More by this author
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Structural Biology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Subgroup:
Structural Biology
Expand authors...
More from this funder
Funding agency for:
Farhy-Tselnicker, I
More from this funder
Funding agency for:
Lee, A
More from this funder
Funding agency for:
Aricescu, AR
More from this funder
Funding agency for:
Allen, NJ
Expand funders...
Publisher:
Elsevier Publisher's website
Journal:
Neuron Journal website
Volume:
96
Issue:
2
Pages:
428-445.e13
Publication date:
2017-10-11
Acceptance date:
2017-09-27
DOI:
EISSN:
1097-4199
ISSN:
0896-6273
Pubs id:
pubs:737202
URN:
uri:d763ee05-ba52-46e7-9f5e-e1dcf3a6ae2a
UUID:
uuid:d763ee05-ba52-46e7-9f5e-e1dcf3a6ae2a
Local pid:
pubs:737202

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP