Journal article : Review
The immunology underlying CNS autoantibody diseases
- Abstract:
- The past two decades have seen a considerable paradigm shift in the way autoimmune CNS disorders are considered, diagnosed, and treated; largely due to the discovery of novel autoantibodies directed at neuroglial surface or intracellular targets. This approach has enabled multiple bona fide CNS autoantibody-associated diseases to thoroughly infiltrate the sphere of clinical neurology, facilitating advances in patient outcomes. This review focusses on the fundamental immunological concepts behind CNS autoantibody-associated diseases. First, we briefly review the broad phenotypic profiles of these conditions. Next, we explore concepts around immune checkpoints and the related B cell lineage. Thirdly, the sources of autoantibody production are discussed alongside triggers of tolerance failure, including neoplasms, infections and iatrogenic therapies. Penultimately, the role of T cells and leucocyte trafficking into the CNS are reviewed. Finally, biological insights from responses to targeted immunotherapies in different CNS autoantibody-associated diseases are summarised. The continued and rapid expansion of the CNS autoantibody-associated field holds promise for further improved diagnostic and therapeutic paradigms, ultimately leading to further improvements in patient outcomes.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 1.5MB, Terms of use)
-
- Publisher copy:
- 10.1016/j.neurol.2024.07.002
Authors
+ Wellcome Trust
More from this funder
- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 104079/Z/14/Z
+ Medical Research Council
More from this funder
- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- MR/V007173/1
- MR/X022013/1
+ National Institute for Health and Care Research
More from this funder
- Funder identifier:
- https://ror.org/0187kwz08
- Grant:
- MR/X022013/1
- Publisher:
- Elsevier
- Journal:
- Revue Neurologique More from this journal
- Volume:
- 180
- Issue:
- 9
- Pages:
- 916-930
- Place of publication:
- France
- Publication date:
- 2024-09-16
- Acceptance date:
- 2024-07-29
- DOI:
- EISSN:
-
2213-0004
- ISSN:
-
0035-3787
- Pmid:
-
39289136
- Language:
-
English
- Keywords:
- Subtype:
-
Review
- Pubs id:
-
2031067
- Local pid:
-
pubs:2031067
- Deposit date:
-
2024-12-10
Terms of use
- Copyright holder:
- Elsevier Masson SAS
- Copyright date:
- 2024
- Rights statement:
- © 2024 Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Elsevier at https://dx.doi.org/10.1016/j.neurol.2024.07.002
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