The synthesis and crystal structure of Cbz-[(1R,2S)-ACPC]3-OH: A tripeptide derived from the β-amino acid (1R,2S)-cispentacin

Journal article

Crystals of the tripeptide Cbz-[(1R,2S)-ACPC]3-OH 4, derived from the β-amino acid (1R,2S)-2-aminocyclopentanecarboxylic acid, were synthesised and studied by X-ray diffraction. Tripeptide 4 crystallizes in the orthorhombic space group P 2 1 2 1 2 1 with cell parameters of a = 7.8957(1) Å, b = 12.9289(2) Å, c = 24.7850(4) Å, V = 2530.12(6) Å3 and Z = 4. Adjacent molecules are linked by a series of N-H···O=C and O- H···O=C hydrogen bonds to form a double tape-like arrangement. Graphical Abstract: The structure of a tripeptide derived from the β-amino acid (1R,2S)-2-aminocyclopentanecarboxylic acid has been analysed by X-ray diffraction.[Figure not available: see fulltext.] © 2014 Springer Science+Business Media New York.

Authors: Davies, S; Siddall, E; Thompson, A; Thomson, J

• Publisher: Springer New York LLC
• Journal: Journal of Chemical Crystallography
• Volume: 44
• Issue: 4
• Pages: 205-209
• Publication date: 2014-01-01
• DOI: 10.1007/s10870-014-0502-x
• EISSN: 1572-8854
• ISSN: 1074-1542
• Language: English
• Keywords: β-Sheet; β-Peptide; Cispentacin