Journal article : Review
Clinical features, investigation, and management of Addison's disease
- Abstract:
- Addison's disease is the manifestation of adrenal glucocorticoid and mineralocorticoid deficiency from T-cell mediated destruction of the adrenal cortex, and is the commonest cause of primary adrenal insufficiency in adults. Due to its vague presentation, diagnosis of Addison's disease is often delayed, and in some cases, individuals present in adrenal crisis. Despite the use of corticosteroid replacement therapy, people with Addison's disease have increased mortality and reduced quality of life. Multiple features are thought to contribute to these outcomes, including inadequacy of adrenal crisis management and the inability of existing therapies to mimic circadian and ultradian rhythms of cortisol release. Current research strategies focus on understanding social and behavioural factors that contribute to adrenal crises, developing therapies that more closely mimic rhythms of physiological cortisol secretion, and developing interventions to restore adrenal steroidogenesis. This Review discusses the clinical features, investigation, and management of Addison's disease.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
-
-
(Preview, Accepted manuscript, pdf, 187.0KB, Terms of use)
-
- Publisher copy:
- 10.1016/s2213-8587(25)00393-6
Authors
+ Medical Research Council
More from this funder
- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- MR/P011462/1
- MR/W015455/1
+ Deutsche Forschungsgemeinschaft
More from this funder
- Funder identifier:
- https://ror.org/018mejw64
+ National Institute for Health and Care Research
More from this funder
- Funder identifier:
- https://ror.org/0187kwz08
- Publisher:
- Elsevier
- Journal:
- Lancet Diabetes & Endocrinology More from this journal
- Volume:
- 14
- Issue:
- 3
- Pages:
- 243-258
- Place of publication:
- England
- Publication date:
- 2026-01-23
- Acceptance date:
- 2025-12-03
- DOI:
- EISSN:
-
2213-8595
- ISSN:
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2213-8587
- Pmid:
-
41587556
- Language:
-
English
- Subtype:
-
Review
- Pubs id:
-
2366438
- Local pid:
-
pubs:2366438
- Deposit date:
-
2026-04-15
- ARK identifier:
Terms of use
- Copyright holder:
- Elsevier Ltd.
- Copyright date:
- 2026
- Rights statement:
- © 2026 Published by Elsevier Ltd. All rights reserved, including those for text and data mining, AI training, and similar technologies.
- Notes:
- The author accepted manuscript (AAM) of this paper has been made available under the University of Oxford's Open Access Publications Policy, and a CC BY public copyright licence has been applied.
- Licence:
- CC Attribution (CC BY)
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