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Achieving a good crystal system for crystallographic X-ray fragment screening
- Abstract:
-
The XChem facility at Diamond Light Source offers fragment screening by X-ray crystallography as a general access user program. The main advantage of X-ray crystallography as a primary fragment screen is that it yields directly the location and pose of the fragment hits, whether within pockets of interest or merely on surface sites: this is the key information for structure-based design and for enabling synthesis of follow-up molecules. Extensive streamlining of the screening experiment at XC...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1016/bs.mie.2018.09.027
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Volume:
- 610
- Pages:
- 251-264
- Series:
- Methods in Enzymology
- Host title:
- Modern Approaches in Drug Discovery
- Publication date:
- 2018-10-15
- DOI:
- ISSN:
-
0076-6879
- Source identifiers:
-
923224
- ISBN:
- 9780128153833
Item Description
- Keywords:
- Pubs id:
-
pubs:934894
- UUID:
-
uuid:d6faff7d-b4d0-4c68-beee-b53351cc258b
- Local pid:
- pubs:934894
- Deposit date:
- 2019-05-10
Terms of use
- Copyright holder:
- Elsevier Inc
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 Elsevier Inc.
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