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Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.

Abstract:

Combinatorial transcription factor (TF) interactions control cellular phenotypes and, therefore, underpin stem cell formation, maintenance, and differentiation. Here, we report the genome-wide binding patterns and combinatorial interactions for ten key regulators of blood stem/progenitor cells (SCL/TAL1, LYL1, LMO2, GATA2, RUNX1, MEIS1, PU.1, ERG, FLI-1, and GFI1B), thus providing the most comprehensive TF data set for any adult stem/progenitor cell type to date. Genome-wide computational ana...

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Publication status:
Published

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Publisher copy:
10.1016/j.stem.2010.07.016

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Journal:
Cell stem cell
Volume:
7
Issue:
4
Pages:
532-544
Publication date:
2010-10-05
DOI:
EISSN:
1875-9777
ISSN:
1934-5909
URN:
uuid:d6dea06d-9525-4298-99ac-1ffb1c146d57
Source identifiers:
325090
Local pid:
pubs:325090

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