Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.

Journal article

Combinatorial transcription factor (TF) interactions control cellular phenotypes and, therefore, underpin stem cell formation, maintenance, and differentiation. Here, we report the genome-wide binding patterns and combinatorial interactions for ten key regulators of blood stem/progenitor cells (SCL/TAL1, LYL1, LMO2, GATA2, RUNX1, MEIS1, PU.1, ERG, FLI-1, and GFI1B), thus providing the most comprehensive TF data set for any adult stem/progenitor cell type to date. Genome-wide computational ana...

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Authors: Wilson, N; Foster, S; Wang, X; Knezevic, K; Schütte, J

• Publication status: Published
• Journal: Cell stem cell
• Volume: 7
• Issue: 4
• Pages: 532-544
• Publication date: 2010-10-01
• DOI: 10.1016/j.stem.2010.07.016
• EISSN: 1875-9777
• ISSN: 1934-5909
• Language: English
• Keywords: Cell Line; Transcription Factors; Gene Expression Regulation; Transcription, Genetic; Genome; Mice; Animals; Stem Cells; Genome-Wide Association Study