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Journal article

A cluster of mutations in HLA-A2 alpha 2 helix abolishes peptide recognition by T cells.

Abstract:

In order to investigate the regions of HLA-A2 that control peptide-specific cytotoxic T lymphocyte (CTL) recognition, 37 HLA-A2 genes coding for 50 point mutations that span the alpha 2 helix were synthesized by the technique of saturation mutagenesis. Twenty-nine of these genes, which code for 41 point mutations, were transfected into C1R cells and used as targets in cytotoxicity assays, in the presence of influenza-A matrix peptide 58-68 with specific CTL as effectors. All the transfectants...

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Publication status:
Published

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Publisher copy:
10.1007/bf00205816

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
Immunogenetics
Volume:
34
Issue:
3
Pages:
141-148
Publication date:
1991-01-01
DOI:
EISSN:
1432-1211
ISSN:
0093-7711
URN:
uuid:d6d20309-5802-4099-b68a-51fe32eb9cd4
Source identifiers:
34434
Local pid:
pubs:34434

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