Journal article icon

Journal article

A cluster of mutations in HLA-A2 alpha 2 helix abolishes peptide recognition by T cells.

Abstract:

In order to investigate the regions of HLA-A2 that control peptide-specific cytotoxic T lymphocyte (CTL) recognition, 37 HLA-A2 genes coding for 50 point mutations that span the alpha 2 helix were synthesized by the technique of saturation mutagenesis. Twenty-nine of these genes, which code for 41 point mutations, were transfected into C1R cells and used as targets in cytotoxicity assays, in the presence of influenza-A matrix peptide 58-68 with specific CTL as effectors. All the transfectants...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1007/bf00205816

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Immunogenetics
Volume:
34
Issue:
3
Pages:
141-148
Publication date:
1991-01-01
DOI:
EISSN:
1432-1211
ISSN:
0093-7711
Source identifiers:
34434
Language:
English
Keywords:
Pubs id:
pubs:34434
UUID:
uuid:d6d20309-5802-4099-b68a-51fe32eb9cd4
Local pid:
pubs:34434
Deposit date:
2012-12-19

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP