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Previous antiretroviral drug use compromises standard first-line HIV therapy and is mediated through drug-resistance

Abstract:

In ART programs in sub-Saharan Africa, a growing proportion of HIV-infected persons initiating first-line antiretroviral therapy (ART) have a history of prior antiretroviral drug use (PAU). We assessed the effect of PAU on the risk of pre-treatment drug resistance (PDR) and virological failure (VF) in a multicountry cohort of HIV-infected adults initiated on a standard non-nucleoside reverse transcriptase inhibitor (NNRTI)-based first-line ART. Multivariate logistic regression was used to ass...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41598-018-33538-0

Authors


Inzaule, SC More by this author
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ORCID:
0000-0001-7424-6060
Wellington, M More by this author
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Publisher:
Springer Nature Publisher's website
Journal:
Scientific reports Journal website
Volume:
8
Pages:
Article: 15751
Publication date:
2018-10-25
Acceptance date:
2018-10-02
DOI:
EISSN:
2045-2322
Pubs id:
pubs:942616
URN:
uri:d6afc2ae-194d-4f69-941e-8e716efafe60
UUID:
uuid:d6afc2ae-194d-4f69-941e-8e716efafe60
Local pid:
pubs:942616
Language:
English

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