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Succinate: a new epigenetic hacker.

Abstract:
Epigenetic reprogramming is a feature of many human cancers. In this issue of Cancer Cell, Letouzé and colleagues describe DNA hypermethylation in paragangliomas harboring mutations in succinate dehydrogenase genes. These tumors accumulate succinate, which inhibits 2-oxoglutarate-dependent histone and DNA demethylase enzymes, resulting in epigenetic silencing that affects neuroendocrine differentiation.
Publication status:
Published

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Publisher copy:
10.1016/j.ccr.2013.05.015

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
Cancer cell
Volume:
23
Issue:
6
Pages:
709-711
Publication date:
2013-06-05
DOI:
EISSN:
1878-3686
ISSN:
1535-6108
URN:
uuid:d6a6a169-5bea-4df1-974f-9cecf0aea6c9
Source identifiers:
403030
Local pid:
pubs:403030

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