Journal article icon

Journal article

Succinate: a new epigenetic hacker.

Abstract:
Epigenetic reprogramming is a feature of many human cancers. In this issue of Cancer Cell, Letouzé and colleagues describe DNA hypermethylation in paragangliomas harboring mutations in succinate dehydrogenase genes. These tumors accumulate succinate, which inhibits 2-oxoglutarate-dependent histone and DNA demethylase enzymes, resulting in epigenetic silencing that affects neuroendocrine differentiation.
Publication status:
Published

Actions

  • Cite

  • Print

Access Document

Publisher copy:
10.1016/j.ccr.2013.05.015

Authors

More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author

Journal:
Cancer cell More from this journal
Volume:
23
Issue:
6
Pages:
709-711
Publication date:
2013-06-01
DOI:
EISSN:
1878-3686
ISSN:
1535-6108

Language:
English
Keywords:
Pubs id:
pubs:403030
UUID:
uuid:d6a6a169-5bea-4df1-974f-9cecf0aea6c9
Local pid:
pubs:403030
Source identifiers:
403030
Deposit date:
2013-11-16
ARK identifier:

Terms of use

Views and Downloads





If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP