The Salmonella translocated effector SopA is targeted to the mitochondria of infected cells.

Journal article

This study investigates the Salmonella effector protein SopA. We show that in Salmonella enterica serovar Dublin-infected cells, SopA(1-347) fused to two carboxy-terminal hemagglutinin tags partially colocalized with mitochondria. Transfection of eukaryotic cells with a panel of constructs encoding truncated versions of SopA identified that amino acids 100 to 347 were sufficient to target SopA to the mitochondria.

Authors: Layton, A; Brown, P; Galyov, E

• Journal: Journal of bacteriology
• Volume: 187
• Issue: 10
• Pages: 3565-3571
• Publication date: 2005-05-01
• DOI: 10.1128/jb.187.10.3565-3571.2005
• EISSN: 1098-5530
• ISSN: 0021-9193
• Language: English
• Keywords: Salmonella Infections; Humans; Salmonella enterica; Mitochondria; Virulence; Subcellular Fractions; Bacterial Proteins; Hela Cells