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Role of the A20-TRAF6 axis in lipopolysaccharide-mediated osteoclastogenesis.

Abstract:

Bacterial lipopolysaccharide (LPS) has long been suggested as a potent inducer of bone loss in vivo despite controversial effects on osteoclast precursors. Recently, the role of the deubiquitinating protease A20 in regulating the LPS response in various organs was reported. In the present study, we investigated whether A20 is expressed in osteoclast cultures in response to RANKL or LPS and whether this protein plays a role in osteoclast formation and activation. Human peripheral blood mononuc...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m110.150300

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
The Journal of biological chemistry
Volume:
286
Issue:
5
Pages:
3242-3249
Publication date:
2011-02-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:d6804c27-3fc4-49ec-809a-41c5e0936f81
Source identifiers:
103906
Local pid:
pubs:103906

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