Journal article
NF-κB-mediated degradation of the coactivator RIP140 regulates inflammatory responses and contributes to endotoxin tolerance.
- Abstract:
-
Tolerance to endotoxins that is triggered by prior exposure to Toll-like receptor (TLR) ligands provides a mechanism with which to dampen inflammatory cytokines. The receptor-interacting protein RIP140 interacts with the transcription factor NF-κB to regulate the expression of genes encoding proinflammatory cytokines. Here we found lipopolysaccharide stimulation of kinase Syk-mediated tyrosine phosphorylation of RIP140 and interaction of the NF-κB subunit RelA with RIP140. These events result...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/ni.2238
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Authors
Bibliographic Details
- Journal:
- Nature immunology
- Volume:
- 13
- Issue:
- 4
- Pages:
- 379-386
- Publication date:
- 2012-04-01
- DOI:
- EISSN:
-
1529-2916
- ISSN:
-
1529-2908
- Source identifiers:
-
316293
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:316293
- UUID:
-
uuid:d62af3ef-3bce-4da1-905b-4c14748eeef0
- Local pid:
- pubs:316293
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2012
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