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The lysosome or lysosome-related organelle may serve as a Ca2+ store in the boutons of hippocampal pyramidal cells.

Abstract:

Boutons are specialised presynaptic compartments that lie along the axons of central neurons. Release of neurotransmitter from boutons is tightly regulated by the level of intracellular calcium [Ca2+]i. A rise in Ca2+ level may be generated in several ways; entry of extracellular Ca2+ via voltage gated calcium channels (VGCCs), entry via ligand-operated channels (LOCs) or the release of Ca2+ from intracellular Ca2+ stores. The role of Ca2+ stores in boutons remains poorly understood, despite ...

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Publication status:
Published

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Authors


McGuinness, L More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
Neuropharmacology
Volume:
52
Issue:
1
Pages:
126-135
Publication date:
2007-01-05
DOI:
EISSN:
1873-7064
ISSN:
0028-3908
URN:
uuid:d6066ada-d5b6-45ef-bfd8-0bf3837e63fd
Source identifiers:
186681
Local pid:
pubs:186681

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