Parental high-fat/high-sugar diets and their lasting impact on brain development in offspring: a longitudinal mouse MRI study

Journal article

Maternal diet and metabolic conditions, such as obesity and diabetes, are associated with consequences for offspring brain health, including effects on behaviour and an increased risk for neurodevelopmental disorders (NDDs). The extent and sequence of neuroanatomical changes to offspring brain development produced by dietary conditions have not yet been reported. In this study, we used a mouse model of parental high-fat or high-fat/high-sugar diet consumption to examine its effects on offspring brain development using longitudinal magnetic resonance imaging. We demonstrated that exposure to these parental diets through gestation and lactation resulted in offspring brain structure changes. Different temporal patterns of change were observed: some structures exhibited volume differences already at postnatal day 3; some of these early appearing changes diminished early in development while others were still present in adulthood; other structure changes were found to emerge later in the pubertal period. Brain changes in adulthood were present despite switching to a healthy diet at weaning. Brain regions impacted included the cingulate cortex, subregions of the hippocampus, and the orbitofrontal cortex, regions previously reported as affected in human NDD populations, with functional roles in reward processing and social cognition, memory, and decision making, respectively. Affected cortical regions, including the cingulate and orbitofrontal cortex, were found to be increased in volume relative to the whole brain, while affected subcortical regions were largely decreased in volume. Our data provide new insights into the long-term neuroanatomical impact of parental diets and how those diets may impact NDD risk. Future studies could use this model to evaluate preventative or ameliorative measures.

Authors: Lee, G; Wilk, K; Chong, C; Yeung, J; Wheeler, AL

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Springer Nature [academic journals on nature.com]
• Journal: Translational Psychiatry
• Volume: 15
• Issue: 1
• Article number: 500
• Publication date: 2025-11-24
• Acceptance date: 2025-10-10
• DOI: 10.1038/s41398-025-03701-z
• EISSN: 2158-3188
• ISSN: 2158-3188
• Language: English