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Conformational changes in a photosensory LOV domain monitored by time-resolved NMR spectroscopy.

Abstract:

Phototropins are light-activated kinases from plants that utilize light-oxygen-voltage (LOV) domains as blue light photosensors. Illumination of these domains leads to the formation of a covalent linkage between the protein and an internally bound flavin chromophore, destabilizing the surrounding protein and displacing an alpha-helix from its surface. Here we use a combination of spectroscopic tools to monitor the kinetic processes that spontaneously occur in the dark as the protein returns t...

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Publication status:
Published

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Publisher copy:
10.1021/ja038224f

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Physical and Theoretical Chem
Role:
Author
Journal:
Journal of the American Chemical Society
Volume:
126
Issue:
11
Pages:
3390-3391
Publication date:
2004-03-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:d5c1c992-e6ad-49cf-812f-73e0b00fccd6
Source identifiers:
32658
Local pid:
pubs:32658

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