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Major subpopulations of Plasmodium falciparum in sub-Saharan Africa

Abstract:

Understanding genomic variation and population structure of Plasmodium falciparum across Africa is necessary to sustain progress toward malaria elimination. Genome clustering of 2263 P. falciparum isolates from 24 malaria-endemic settings in 15 African countries identified major western, central, and eastern ancestries, plus a highly divergent Ethiopian population. Ancestry aligned to these regional blocs, overlapping with both the parasite's origin and with historical human migration. The pa...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/science.aav5427

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Role:
Author
ORCID:
0000-0003-4478-3601
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Role:
Author
ORCID:
0000-0003-4468-0506
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Role:
Author
ORCID:
0000-0002-5761-7883
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Role:
Author
ORCID:
0000-0001-8633-9221
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Name:
Wellcome Trust
Grant:
204911/Z/16/Z
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Name:
Medical Research Council
Grant:
MR/M006212/1
Publisher:
American Association for the Advancement of Science
Journal:
Science More from this journal
Volume:
365
Issue:
6455
Pages:
813–816
Publication date:
2019-08-23
Acceptance date:
2019-07-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Pmid:
31439796
Language:
English
Keywords:
Pubs id:
pubs:1048179
UUID:
uuid:d5c01a06-dbe0-4e07-89a9-d1e3d1b49fec
Local pid:
pubs:1048179
Source identifiers:
1048179
Deposit date:
2019-09-18

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