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NOD2 and TLR2 signal via TBK1 and PI31 to direct cross-presentation and CD8 T cell responses

Abstract:

NOD2 and TLR2 recognize components of bacterial cell wall peptidoglycan and direct defense against enteric pathogens. CD8+ T cells are important for immunity to such pathogens but how NOD2 and TLR2 induce antigen specific CD8+ T cell responses is unknown. Here, we define how these pattern recognition receptors (PRRs) signal in primary dendritic cells (DCs) to influence MHC class I antigen presentation. We show NOD2 and TLR2 phosphorylate PI31 via TBK1 following activation in DCs. PI31 interac...

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Publication status:
Published
Peer review status:
Peer reviewed

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Name:
Wellcome Trust
Grant:
102974/Z/13/Z
Publisher:
Frontiers Media
Journal:
Frontiers in Immunology More from this journal
Volume:
10
Publication date:
2019-04-30
Acceptance date:
2019-04-15
DOI:
ISSN:
1664-3224
Keywords:
Pubs id:
pubs:998154
UUID:
uuid:d59ae326-835e-4c2e-934c-53970b2af4ea
Local pid:
pubs:998154
Source identifiers:
998154
Deposit date:
2019-05-16

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