Recovery from Covid-19 critical illness: a secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial

Pauley, E; Drake, TM; Griffith, DM; Sigfrid, L; Lone, NI; Harrison, EM; Baillie, JK; Scott, JT; Walsh, TS; Semple, MG; Docherty, AB

COVID-19 Collection

Journal article

Recovery from Covid-19 critical illness: a secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial

Abstract:: Background: We aimed to compare the prevalence and severity of fatigue in survivors of Covid-19 versus non-Covid-19 critical illness, and to explore potential associations between baseline characteristics and worse recovery.

Methods: We conducted a secondary analysis of two prospectively collected datasets. The population included was 92 patients who received invasive mechanical ventilation (IMV) with Covid-19, and 240 patients who received IMV with non-Covid-19 illness before the pandemic. Follow-up data were collected post-hospital discharge using self-reported questionnaires. The main outcome measures were self-reported fatigue severity and the prevalence of severe fatigue (severity >7/10) 3 and 12-months post-hospital discharge.

Results: Covid-19 IMV-patients were significantly younger with less prior comorbidity, and more males, than pre-pandemic IMV-patients. At 3-months, the prevalence (38.9% [7/18] vs. 27.1% [51/188]) and severity (median 5.5/10 vs 5.0/10) of fatigue were similar between the Covid-19 and pre-pandemic populations, respectively. At 6-months, the prevalence (10.3% [3/29] vs. 32.5% [54/166]) and severity (median 2.0/10 vs. 5.7/10) of fatigue were less in the Covid-19 cohort. In the total sample of IMV-patients included (i.e. all Covid-19 and pre-pandemic patients), having Covid-19 was significantly associated with less severe fatigue (severity <7/10) after adjusting for age, sex and prior comorbidity (adjusted OR 0.35 (95%CI 0.15–0.76, p=0.01).

Conclusion: Fatigue may be less severe after Covid-19 than after other critical illness.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Pauley, E., Drake, T. M., Griffith, D. M., Sigfrid, L., Lone, N. I., Harrison, E. M., Baillie, J. K., Scott, J. T., Walsh, T. S., Semple, M. G., & Docherty, A. B. (2021). Recovery from Covid-19 critical illness: a secondary analysis of the ISARIC4C CCP-UK cohort study and the RECOVER trial. Journal of the Intensive Care Society, 24(2), 162–169.

MLA Style

Pauley, E, et al. “Recovery from Covid-19 Critical Illness: a Secondary Analysis of the ISARIC4C CCP-UK Cohort Study and the RECOVER Trial.” Journal of the Intensive Care Society, vol. 24, no. 2, 2021, pp. 162–69.

Chicago Style

Pauley, E, TM Drake, DM Griffith, et al. 2021. “Recovery from Covid-19 Critical Illness: a Secondary Analysis of the ISARIC4C CCP-UK Cohort Study and the RECOVER Trial.” Journal of the Intensive Care Society 24 (2): 162–69.
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