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Dynamic interaction of amphiphysin with N-WASP regulates actin assembly.

Abstract:

Amphiphysin 1, an endocytic adaptor concentrated at synapses that couples clathrin-mediated endocytosis to dynamin-dependent fission, was also shown to have a regulatory role in actin dynamics. Here, we report that amphiphysin 1 interacts with N-WASP and stimulates N-WASP- and Arp2/3-dependent actin polymerization. Both the Src homology 3 and the N-BAR domains are required for this stimulation. Acidic liposome-triggered, N-WASP-dependent actin polymerization is strongly impaired in brain cyto...

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Publisher copy:
10.1074/jbc.m109.064204

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Journal:
The Journal of biological chemistry
Volume:
284
Issue:
49
Pages:
34244-34256
Publication date:
2009-12-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:d56bec46-d52d-4a65-906f-b16968d8225a
Source identifiers:
394787
Local pid:
pubs:394787

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