Increased numbers of DNA-damaged spermatozoa in samples presenting an elevated rate of numerical chromosome abnormalities.
STUDY QUESTION: Is there a relationship between DNA damage and numerical chromosome abnormalities in the sperm of infertile patients? SUMMARY ANSWER: A strong link between DNA fragmentation and the presence of numerical chromosome abnormalities was detected in human sperm. Chromosomally abnormal spermatozoa were more likely to be affected by DNA fragmentation than those that were chromosomally normal. WHAT IS KNOWN ALREADY: Several studies have described the presence of elevated levels of DN...Expand abstract
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