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Journal article

Inertial cavitation to non-invasively trigger and monitor intratumoral release of drug from intravenously delivered liposomes.

Abstract:

The encapsulation of cytotoxic drugs within liposomes enhances pharmacokinetics and allows passive accumulation within tumors. However, liposomes designed to achieve good stability during the delivery phase often have compromised activity at the target site. This problem of inefficient and unpredictable drug release is compounded by the present lack of low-cost, non-invasive methods to measure such release. Here we show that focused ultrasound, used at pressures similar to those applied durin...

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Publication status:
Published

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Journal:
Journal of controlled release : official journal of the Controlled Release Society More from this journal
Volume:
178
Issue:
1
Pages:
101-107
Publication date:
2014-03-01
DOI:
EISSN:
1873-4995
ISSN:
0168-3659
Language:
English
Keywords:
Pubs id:
pubs:444104
UUID:
uuid:d536e548-741d-4a53-bc2a-811c80522380
Local pid:
pubs:444104
Source identifiers:
444104
Deposit date:
2014-07-22

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