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Associations of plasma fibrinogen levels with established cardiovascular disease risk factors, inflammatory markers, and other characteristics: individual participant meta-analysis of 154,211 adults in 31 prospective studies: the fibrinogen studies collaboration.

Abstract:

Long-term increases in plasma fibrinogen levels of 1 g/liter are associated with an approximate doubling of risk of major cardiovascular disease outcomes, but causality remains uncertain. To quantify cross-sectional associations of fibrinogen levels with established risk factors and other characteristics, the investigators combined individual data on 154,211 apparently healthy adults from 31 prospective studies conducted between 1967 and 2003, using a linear mixed model that included random e...

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Publication status:
Published

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Publisher copy:
10.1093/aje/kwm191

Authors


Kaptoge, S More by this author
Thompson, SG More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
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Journal:
American journal of epidemiology
Volume:
166
Issue:
8
Pages:
867-879
Publication date:
2007-10-05
DOI:
EISSN:
1476-6256
ISSN:
0002-9262
URN:
uuid:d5208dbd-f1fb-4c92-ab85-2847aee08f43
Source identifiers:
33956
Local pid:
pubs:33956

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