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Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza

Abstract:

Transcriptional profiles and host-response biomarkers are used increasingly to investigate the severity, subtype and pathogenesis of disease. We now describe whole-blood mRNA signatures and concentrations of local and systemic immunological mediators in 131 adults hospitalized with influenza, from whom extensive clinical and investigational data were obtained by MOSAIC investigators. Signatures reflective of interferon-related antiviral pathways were common up to day 4 of symptoms in patients...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41590-018-0111-5

Authors


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Role:
Author
ORCID:
0000-0001-9602-9075
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Role:
Author
ORCID:
0000-0002-6808-6758
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Role:
Author
ORCID:
0000-0002-4002-1506
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Name:
Wellcome Trust
Grant:
090382/Z/09/Z
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Name:
Medical Research Council
Grant:
090382/Z/09/Z
Publisher:
Nature Publishing Group
Journal:
Nature Immunology More from this journal
Volume:
19
Issue:
6
Pages:
625-635
Publication date:
2018-05-18
Acceptance date:
2018-04-13
DOI:
ISSN:
1529-2908 and 1529-2916
Pmid:
29777224
Language:
English
Keywords:
Pubs id:
pubs:854201
UUID:
uuid:d4cadf1a-368b-47ce-93e8-57cf3db105f4
Local pid:
pubs:854201
Source identifiers:
854201
Deposit date:
2018-12-06

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