Computational simulation of the flow dynamic field in a porous ureteric stent

Journal article

Ureteric stents are employed clinically to manage urinary obstructions or other pathological conditions. Stents made of porous and biodegradable materials have gained increasing interest, because of their excellent biocompatibility and the potential for overcoming the so-called ‘forgotten stent syndrome’. However, there is very limited characterisation of their flow dynamic performance. In this study, a CFD model of the occluded and unoccluded urinary tract was developed to investigate the urinary flow dynamics in the presence of a porous ureteric stent. With increasing the permeability of the porous material (i.e., from 10⁻¹⁸ to 10⁻¹⁰ m²) both the total mass flow rate through the ureter and the average fluid velocity within the stent increased. In the unoccluded ureter, the total mass flow rate increased of 7.7% when a porous stent with permeability of 10⁻¹⁰ m² was employed instead of an unporous stent. Drainage performance further improved in the presence of a ureteral occlusion, with the porous stent resulting in 10.2% greater mass flow rate compared to the unporous stent. Findings from this study provide fundamental insights into the flow performance of porous ureteric stents, with potential utility in the development pipeline of these medical devices.

Authors: Yang, X; Mosayyebi, A; Carugo, D

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Springer
• Journal: Medical and Biological Engineering and Computing
• Volume: 60
• Issue: 8
• Pages: 2373-2387
• Publication date: 2022-06-28
• Acceptance date: 2022-06-15
• DOI: 10.1007/s11517-022-02620-1
• EISSN: 1741-0444
• ISSN: 0140-0118
• Pmid: 35763188
• Language: English
• Keywords: porous material; ureteral stent; ureteral obstruction; computer fluid dynamics; FFR