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Ageing compromises mouse thymus function and remodels epithelial cell differentiation

Abstract:

Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the molecular and cellular mechanisms underpinning these ageing processes remain unclear. Here, we show that mouse ageing leads to less efficient T cell selection, decreased self-antigen representation and increased T cell receptor repertoire diversity. ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/eLife.56221

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Name:
Wellcome Trust
Grant:
105045/Z/14/Z
Publisher:
eLife Sciences Publications
Journal:
eLife More from this journal
Volume:
9
Article number:
e56221
Publication date:
2020-09-14
Acceptance date:
2020-06-08
DOI:
EISSN:
2050-084X
Language:
English
Keywords:
Pubs id:
1110290
Local pid:
pubs:1110290
Deposit date:
2020-06-08

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