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The functional consequences of 11beta-hydroxysteroid dehydrogenase expression in adipose tissue.

Abstract:

Clinical observations have highlighted the link between glucocorticoids and obesity. While exogenous glucocorticoids in excess predispose to the development of central obesity, we have focused on cortisol metabolism within human adipose tissue. 11beta-hydroxysteroid dehydrogenase (11beta-HSD) inter-converts the active glucocorticoid, cortisol, and inactive cortisone. 11beta-HSD1, the only isoform expressed in adipose tissue, acts predominantly as an oxoreductase to generate cortisol. Expressi...

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Publication status:
Published

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Publisher copy:
10.1055/s-2002-38242

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, RDM
Stewart, PM More by this author
Journal:
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
Volume:
34
Issue:
11-12
Pages:
746-751
Publication date:
2002
DOI:
EISSN:
1439-4286
ISSN:
0018-5043
URN:
uuid:d4884a4b-5803-4a93-bce9-8e26ac84aba9
Source identifiers:
482109
Local pid:
pubs:482109

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