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Identification of SLC41A3 as a novel player in magnesium homeostasis.

Abstract:

Regulation of the body Mg(2+) balance takes place in the distal convoluted tubule (DCT), where transcellular reabsorption determines the final urinary Mg(2+) excretion. The basolateral Mg(2+) extrusion mechanism in the DCT is still unknown, but recent findings suggest that SLC41 proteins contribute to Mg(2+) extrusion. The aim of this study was, therefore, to characterize the functional role of SLC41A3 in Mg(2+) homeostasis using the Slc41a3 knockout (Slc41a3(-/-)) mouse. By quantitative PCR ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/srep28565

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Arjona, FJ More by this author
van den Brand, M More by this author
Lavrijsen, M More by this author
Lameris, ALL More by this author
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Funding agency for:
de Baaij, JHF
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Grant:
(FP7/2007–2013) no 305608
Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Pages:
28565
Publication date:
2016-06-28
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
URN:
pubs:d459f3d2-0511-4452-b494-b27f25d4df20
Source identifiers:
633119
Local pid:
info:fedora/pubs:633119
Language:
English
Keywords:

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