Journal article icon

Journal article

Recommended guidelines for validation, quality control, and reporting of TP53 variants in clinical practice

Abstract:

Accurate assessment of TP53 gene status in sporadic tumors and in the germline of individuals at high risk of cancer due to Li-Fraumeni Syndrome (LFS) has important clinical implications for diagnosis, surveillance, and therapy. Genomic data from more than 20,000 cancer genomes provide a wealth of information on cancer gene alterations and have confirmed TP53 as the most commonly mutated gene in human cancer. Analysis of a database of 70,000 TP53 variants reveals that the two newly discovered...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1158/0008-5472.CAN-16-2179

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
Publisher:
American Association for Cancer Research
Journal:
Cancer Research More from this journal
Volume:
77
Issue:
6
Pages:
1250-1260
Publication date:
2017-03-14
Acceptance date:
2016-11-16
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
Language:
English
Keywords:
Pubs id:
pubs:685309
UUID:
uuid:d449c670-bbe9-4468-b74b-febc7c296fa7
Local pid:
pubs:685309
Source identifiers:
685309
Deposit date:
2017-04-11

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP