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The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA

Abstract:

AbstractTermination of RNA polymerase II (Pol II) transcription is an important step in the transcription cycle, which involves the dislodgement of polymerase from DNA, leading to release of a functional transcript. Recent studies have identified the key players required for this process and showed that a common feature of these proteins is a conserved domain that interacts with the phosphorylated C-terminus of Pol II (CTD-interacting domain, CID). However, the mechanism by which transcriptio...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/ncomms14861

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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Issue:
1
Pages:
14861
Acceptance date:
2016-04-03
DOI:
EISSN:
2041-1723
Pubs id:
pubs:667829
URN:
uri:d4433d0f-d17c-4df6-8691-f1ce25ed1a97
UUID:
uuid:d4433d0f-d17c-4df6-8691-f1ce25ed1a97
Local pid:
pubs:667829
Paper number:
1

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