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CRP, IL-6 and depression: A systematic review and meta-analysis of longitudinal studies

Abstract:

Background: Inflammatory markers are raised in cross-sectional studies of depressed patients and may represent an important mediating factor for behaviour, neural plasticity and brain structure. Methods: We undertook a systematic review of longitudinal studies, investigating whether raised inflammatory markers indicate an increased risk of subsequent depressive symptoms. We searched three databases (1970-2012) for longitudinal studies with repeat data on CRP or IL-6 levels and subsequent depr...

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Publisher copy:
10.1016/j.jad.2013.06.004

Authors


Valkanova, V More by this author
Ebmeier, KP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Journal:
Journal of Affective Disorders
Volume:
150
Issue:
3
Pages:
736-744
Publication date:
2013-09-25
DOI:
EISSN:
1573-2517
ISSN:
0165-0327
URN:
uuid:d413ab19-32cb-4895-a092-a1144158182c
Source identifiers:
441209
Local pid:
pubs:441209

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