Journal article
A hyaluronic acid granular hydrogel nerve guidance conduit promotes regeneration and functional recovery of injured sciatic nerves in rats
- Abstract:
- A hyaluronic acid granular hydrogel can promote neuronal and astrocyte colony formation and axonal extension in vitro, suggesting that the hydrogel can simulate an extracellular matrix structure to promote neural regeneration. However, in vivo experiments have not been conducted. In this study, we transplanted a hyaluronic acid granular hydrogel nerve guidance conduit to repair a 10-mm long sciatic nerve gap. The Basso, Beattie, and Bresnahan locomotor rating scale, sciatic nerve compound muscle action potential recording, Fluoro-Gold retrograde tracing, growth related protein 43/S100 immunofluorescence staining, transmission electron microscopy, gastrocnemius muscle dry/wet weight ratio, and Masson’s trichrome staining results showed that the nerve guidance conduit exhibited similar regeneration of sciatic nerve axons and myelin sheath, and recovery of the electrophysiological function and motor function as autologous nerve transplantation. The conduit results were superior to those of a bulk hydrogel or silicone tube transplant. These findings suggest that tissue-engineered nerve conduits containing hyaluronic acid granular hydrogels effectively promote the morphological and functional recovery of the injured sciatic nerve. The nerve conduits have the potential as a material for repairing peripheral nerve defects.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 6.1MB, Terms of use)
-
- Publisher copy:
- 10.4103/1673-5374.350212
Authors
- Publisher:
- Medknow Publications
- Journal:
- Neural Regeneration Research More from this journal
- Volume:
- 18
- Issue:
- 3
- Pages:
- 657-663
- Publication date:
- 2022-08-02
- Acceptance date:
- 2022-06-08
- DOI:
- EISSN:
-
1876-7958
- ISSN:
-
1673-5374
- Pmid:
-
36018191
- Language:
-
English
- Keywords:
- Pubs id:
-
1278068
- Local pid:
-
pubs:1278068
- Deposit date:
-
2022-09-14
Terms of use
- Copyright holder:
- Neural Regeneration Research
- Copyright date:
- 2023
- Rights statement:
- © 2023 Neural Regeneration Research. This is an open access journal, and articles are distributed under the terms of the Creative Commons AttributionNonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
If you are the owner of this record, you can report an update to it here: Report update to this record