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Journal article

Specificity, cross-reactivity, and function of antibodies elicited by Zika virus infection

Abstract:

Zika virus (ZIKV), a mosquito-borne flavivirus with homology to Dengue virus (DENV), has become a public health emergency. By characterizing memory lymphocytes from ZIKV-infected patients, we dissected ZIKV-specific and DENV-cross-reactive immune responses. Antibodies to nonstructural protein 1 (NS1) were largely ZIKV-specific and were used to develop a serological diagnostic tool. In contrast, antibodies against E protein domain I/II (EDI/II) were cross-reactive and, although poorly neutrali...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/science.aaf8505

Authors


Publisher:
American Association for the Advancement of Science
Journal:
Science More from this journal
Volume:
353
Issue:
6301
Pages:
823-826
Publication date:
2016-08-01
Acceptance date:
2016-07-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Pmid:
27417494
Language:
English
Keywords:
Pubs id:
pubs:635439
UUID:
uuid:d3d2bbd6-0dae-4a74-ae5d-be888a21f426
Local pid:
pubs:635439
Source identifiers:
635439
Deposit date:
2016-10-12

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