Beam control system and output fine-tuning for safe and precise delivery of FLASH radiotherapy at a clinical linear accelerator

Journal article

Irradiations at Ultra High Dose Rate (UHDR) regimes, exceeding 40 Gy/s in single fractions lasting less than 200 ms, have shown an equivalent antitumor effect compared to conventional radio-therapy with reduced harm to normal tissues. This work details the hardware and software modi-fications implemented to deliver 10 MeV UHDR electron beams with a Linear Accelerator Elekta SL 18 MV and the beam characteristics obtained. GafChromic EBT XD films and an Advanced Markus chamber were used for the dosimetry characterization, while a silicon sensor assessed the machine\u27s beam pulses stability and repeatability. Dose per pulse, average dose rate and instantaneous dose rate in the pulse were evaluated for four experimental settings, varying the source-to-surface dis-tance and the beam collimation, i.e. with and without the use of a cylindrical applicator. Results showed dose per pulse from 0.6 Gy to a few tens of Gy and average dose rate up to 300 Gy/s. The obtained results demonstrate the possibility to perform in-vitro radiobiology experiments and test of new technologies for beam monitoring and dosimetry at the upgraded LINAC, thus contributing to the electron UHDR research field

Authors: Konradsson, E; Wahlqvist, P; Thoft, A; Blad, B; Bäck, S

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Frontiers Media
• Journal: Frontiers in Oncology
• Volume: 14
• Pages: 1342488-1342488
• Article number: 1342488
• Publication date: 2024-01-18
• DOI: 10.3389/fonc.2024.1342488
• EISSN: 2234-943X
• ISSN: 2234-943X
• Language: English
• Keywords: Materials science; Physics; Dosimeter; Imaging phantom; Linear particle accelerator; Computer science; Optics; Detector; Flash (photography); Isocenter; Truebeam; Beam (structure); Radiation