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Investigation of early T cell activation: analysis of the effect of specific antigen, interleukin 2 and monoclonal antibodies on intracellular free calcium concentration.

Abstract:

The three mitogenic anti-T3 antibodies, UCHT1, anti-Leu-4 and WT-32, all produce a rapid increase in T cell intracellular Ca2+ ( [Ca2+]i) in all individuals, as measured by quin 2 tetra-acetoxymethyl ester fluorescence. This indicates that the lack of responsiveness of approximately 30% of individuals to UCHT1 in proliferation assays is not due to failure of the antibody to elicit Ca2+ mobilization and that a rise in [Ca2+]i is per se not adequate to induce cell division. Another mitogenic an...

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Publisher copy:
10.1002/eji.1830150103

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
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Journal:
European journal of immunology
Volume:
15
Issue:
1
Pages:
7-11
Publication date:
1985-01-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:d39b600c-be5e-4ced-a567-2b9727514816
Source identifiers:
35199
Local pid:
pubs:35199

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