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Super-resolution microscopy reveals compartmentalization of peroxisomal membrane proteins

Abstract:

Membrane-associated events during peroxisomal protein import processes play an essential role in peroxisome functionality. Many details of these processes are not known due to missing spatial resolution of technologies capable of investigating peroxisomes directly in the cell. Here, we present the use of super-resolution optical stimulated emission depletion microscopy to investigate with sub-60-nm resolution the heterogeneous spatial organization of the peroxisomal proteins PEX5, PEX14, and ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1074/jbc.M116.734038

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
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Name:
Wellcome Trust
Grant:
104924/14/Z/14
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Name:
Biotechnology and Biological Sciences Research Council
Grant:
MR/K01577X/1
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Name:
Medical Research Council
Grant:
MR/K01577X/1
More from this funder
Name:
Deutsche Forschungsgemeinschaft
Publisher:
American Society for Biochemistry and Molecular Biology
Journal:
Journal of biological chemistry More from this journal
Volume:
291
Issue:
33
Pages:
16948-16962
Publication date:
2016-06-16
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Pmid:
27311714
Language:
English
Keywords:
Pubs id:
pubs:631065
UUID:
uuid:d397889d-7788-4088-8cf1-6fb1b93d6667
Local pid:
pubs:631065
Source identifiers:
631065
Deposit date:
2017-03-18

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