T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1.

Journal article

Effective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechanism between lymphocyte function-associated molecule-1 (LFA-1) and intercellular adhesion molecules (ICAMs), with intracellular signals transmitted from the T-cell antigen receptor to the LFA-1 adhesion molecule. The increase in avidity is rapid and transient, providing a dynamic mechanism for antigen-specific regulation of lymphocyte adhesion and de-adhesion.

Authors: Dustin, M; Springer, T

• Journal: Nature
• Volume: 341
• Issue: 6243
• Pages: 619-624
• Publication date: 1989-10-01
• DOI: 10.1038/341619a0
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Humans; T-Lymphocytes; Receptors, Leukocyte-Adhesion; Micelles; Lymphocyte Function-Associated Antigen-1; Receptors, Antigen, T-Cell; 1-Methyl-3-isobutylxanthine; Cell Adhesion; Lymphocyte Activation; Staurosporine; Bucladesine; Forskolin; Alkaloids; Antigens, Differentiation; Temperature; Phorbol Esters; Cell Adhesion Molecules