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Journal article

The enzymes of beta-lactam biosynthesis

Abstract:

Covering: up to May 2012 The β-lactam antibiotics and related β-lactamase inhibitors are amongst the most important small molecules in clinical use. Most, but not all, β-lactams including penicillins, cephalosporins, and clavulanic acid are produced via fermentation or via modification of fermented intermediates, with important exceptions being the carbapenems and aztreonam. The desire for more efficient routes to existing antibiotics and for access to new and synthetically challenging ones s...

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Publication status:
Published

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Publisher copy:
10.1039/c2np20065a

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Journal:
NATURAL PRODUCT REPORTS
Volume:
30
Issue:
1
Pages:
21-107
Publication date:
2013-01-01
DOI:
EISSN:
1460-4752
ISSN:
0265-0568
URN:
uuid:d34ffaa4-f001-4058-8976-5f307b4ebee7
Source identifiers:
368143
Local pid:
pubs:368143
Language:
English

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