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Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma.

Abstract:

Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, and prior attempts to develop genomic-based classification for HCC have yielded highly divergent results, indicating difficulty in identifying unified molecular anatomy. We performed a meta-analysis of gene expression profiles in data sets from eight independent patient cohorts across the world. In addition, aiming to establish the real world applicability of a classification system, we profiled 118 formalin-fixed, paraffin-emb...

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Authors


Hoshida, Y More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
Kobayashi, M More by this author
Brunet, JP More by this author
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Journal:
Cancer research
Volume:
69
Issue:
18
Pages:
7385-7392
Publication date:
2009-09-05
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
URN:
uuid:d32f13da-9bda-42d2-999b-dfbdb5e4c680
Source identifiers:
489969
Local pid:
pubs:489969

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