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Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2.

Abstract:

Polycystin-2 (PC2), a calcium-activated cation TRP channel, is involved in diverse Ca(2+) signaling pathways. Malfunctioning Ca(2+) regulation in PC2 causes autosomal-dominant polycystic kidney disease. Here we report two cryo-EM structures of distinct channel states of full-length human PC2 in complex with lipids and cations. The structures reveal conformational differences in the selectivity filter and in the large exoplasmic domain (TOP domain), which displays differing N-glycosylation. Th...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nsmb.3357

Authors


More from this funder
Name:
Horizon 2020
Funding agency for:
Huiskonen, J
Grant:
649053
More from this funder
Name:
Wellcome Trust
Funding agency for:
Grieben, M
Pike, A
Huiskonen, J
Carpenter, E
Grant:
092809/Z/10/Z
092809/Z/10/Z
649053
092809/Z/10/Z
093305/Z/10/Z
More from this funder
Name:
Structural Genetics Consortium
Funding agency for:
Grieben, M
Pike, A
Carpenter, E
Grant:
092809/Z/10/Z
092809/Z/10/Z
092809/Z/10/Z
More from this funder
Name:
German Research Foundation
Grant:
SFB807
Publisher:
Nature Publishing Group
Journal:
Nature Structural and Molecular Biology More from this journal
Volume:
24
Issue:
2
Pages:
123-130
Publication date:
2017-01-01
Acceptance date:
2016-12-08
DOI:
EISSN:
1545-9993
ISSN:
1545-9985
Language:
English
Keywords:
Pubs id:
pubs:671415
UUID:
uuid:d32cbacd-4847-45f8-a08a-d94a3efe58d3
Local pid:
pubs:671415
Source identifiers:
671415
Deposit date:
2017-02-28

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