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Investigating the role of Dis2 phosphatase in RNA Polymerase II transcription termination in fission yeast

Abstract:

The end of the RNA polymerase II (Pol II) transcription cycle is a tightly regulated process that requires: (i) dissociation of elongation factors, (ii) recruitment of the 3' end processing machinery that is essential for premRNA cleavage and polyadenylation, and (iii) association of termination factors to dislodge Pol II from the DNA template. A characteristic feature of termination factors is that they directly interact with the phosphorylated C-terminal domain (CTD) of the largest...

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Department:
Biochemistry
Role:
Author

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Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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