Journal article

Assessment of hand-held Raman instrumentation for in situ screening for potentially counterfeit artesunate antimalarial tablets by FT-Raman spectroscopy and direct ionization mass spectrometry.

Abstract:: Pharmaceutical counterfeiting has become a significant public health problem worldwide and new, rapid, user-friendly, reliable and inexpensive methods for drug quality screening are needed. This work illustrates the chemical characterization of genuine and fake artesunate antimalarial tablets by portable Raman spectroscopy and validation by FT-Raman spectroscopy and ambient mass spectrometry. The applicability of a compact and robust portable Raman spectrometer (TruScan) for the in situ chemical identification of counterfeit tablets is reported.

Publication status:: Published

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APA Style

Ricci, C., Nyadong, L., Yang, F., Fernandez, F., Brown, C., Newton, P., & Kazarian, S. (2008). Assessment of hand-held Raman instrumentation for in situ screening for potentially counterfeit artesunate antimalarial tablets by FT-Raman spectroscopy and direct ionization mass spectrometry. Analytica Chimica Acta, 623(2), 178–186.

MLA Style

Ricci, C., et al. “Assessment of Hand-Held Raman Instrumentation for in Situ Screening for Potentially Counterfeit Artesunate Antimalarial Tablets by FT-Raman Spectroscopy and Direct Ionization Mass Spectrometry.” Analytica Chimica Acta, vol. 623, no. 2, 2008, pp. 178–86.

Chicago Style

Ricci, C, L Nyadong, F Yang, F Fernandez, C Brown, P Newton, and S Kazarian. 2008. “Assessment of Hand-Held Raman Instrumentation for in Situ Screening for Potentially Counterfeit Artesunate Antimalarial Tablets by FT-Raman Spectroscopy and Direct Ionization Mass Spectrometry.” Analytica Chimica Acta 623 (2): 178–86.
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Publisher copy:: 10.1016/j.aca.2008.06.007

Authors

+ Ricci, C More by this author

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+ Nyadong, L More by this author

Role:: Author

+ Yang, F More by this author

Role:: Author

+ Fernandez, F More by this author

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+ Brown, C More by this author

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Journal:: Analytica chimica acta More from this journal
Volume:: 623
Issue:: 2
Pages:: 178-186
Publication date:: 2008-08-01
DOI:: 10.1016/j.aca.2008.06.007
EISSN:: 1873-4324
ISSN:: 0003-2670

Language:: English
Keywords:: Mass Spectrometry

Fraud

Fourier Analysis

Tablets

Spectrum Analysis, Raman

Artemisinins

Quality Control

Antimalarials

Reproducibility of Results
Pubs id:: pubs:22662
UUID:: uuid:d3271be9-d599-403a-9dcb-59151865085f
Local pid:: pubs:22662
Source identifiers:: 22662
Deposit date:: 2012-12-19

Terms of use

Copyright date:: 2008

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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