Journal article
Ion channel trafficking: Control of ion channel density as a target for arrhythmias?
- Abstract:
- The shape of the cardiac action potential (AP) is determined by the contributions of numerous ion channels. Any dysfunction in the proper function or expression of these ion channels can result in a change in effective refractory period (ERP) and lead to arrhythmia. The processes underlying the correct targeting of ion channels to the plasma membrane are complex, and have not been fully characterized in cardiac myocytes. Emerging evidence highlights ion channel trafficking as a potential causative factor in certain acquired and inherited arrhythmias, and therapies which target trafficking as opposed to pore block are starting to receive attention. In this review we present the current evidence for the mechanisms which underlie precise control of cardiac ion channel trafficking and targeting.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 490.0KB, Terms of use)
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- Publisher copy:
- 10.3389/fphys.2017.00808
Authors
- Publisher:
- Frontiers Media
- Journal:
- Frontiers in Physiology More from this journal
- Volume:
- 8
- Article number:
- 808
- Publication date:
- 2017-10-17
- Acceptance date:
- 2017-10-02
- DOI:
- EISSN:
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1664-042X
- Pmid:
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29089904
- Language:
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English
- Keywords:
- Pubs id:
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pubs:742373
- UUID:
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uuid:d32283a9-b266-479c-a315-ee03a1214bef
- Local pid:
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pubs:742373
- Source identifiers:
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742373
- Deposit date:
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2019-06-19
- ARK identifier:
Terms of use
- Copyright holder:
- Balse et al
- Copyright date:
- 2017
- Notes:
- © 2017 Balse and Boycott. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Licence:
- CC Attribution (CC BY)
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