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Orthobunyavirus ultrastructure and the curious tripodal glycoprotein spike.

Abstract:

The genus Orthobunyavirus within the family Bunyaviridae constitutes an expanding group of emerging viruses, which threaten human and animal health. Despite the medical importance, little is known about orthobunyavirus structure, a prerequisite for understanding virus assembly and entry. Here, using electron cryo-tomography, we report the ultrastructure of Bunyamwera virus, the prototypic member of this genus. Whilst Bunyamwera virions are pleomorphic in shape, they display a locally ordered ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.ppat.1003374

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine
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Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
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Author
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Funding agency for:
Bowden, TA
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Funding agency for:
Huiskonen, JT
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS pathogens Journal website
Volume:
9
Issue:
5
Pages:
e1003374
Publication date:
2013-01-01
DOI:
EISSN:
1553-7374
ISSN:
1553-7366
URN:
uuid:d31f1d94-92e3-43d0-b636-6697fc6b165c
Source identifiers:
400680
Local pid:
pubs:400680

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