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Stringent thresholds in SARS-CoV-2 IgG assays lead to under-detection of mild infections

Abstract:

Background
Thresholds for SARS-CoV-2 antibody assays have typically been determined using samples from symptomatic, often hospitalised, patients. In this setting the sensitivity and specificity of the best performing assays can both exceed 98%. However, antibody assay performance following mild infection is less clear.
Methods
We assessed quantitative IgG responses in a cohort of healthcare workers in Oxford, UK, with a high pre-test probabil... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Sub department:
BH NDM STRATEGIC; BX POPULATION HEALTH; H6 CLINICAL TRIAL SERVICE UNIT
Role:
Author
ORCID:
0000-0001-5095-6367
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0001-6825-9324
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
ORCID:
0000-0002-4508-7969
More from this funder
Name:
Wellcome Trust
Grant:
214560/Z/18/Z
095541/A/11/Z
More from this funder
Name:
Medical Research Council
Grant:
MR/N00065X/1
G1100525
Publisher:
BioMed Central
Journal:
BMC Infectious Diseases More from this journal
Volume:
21
Issue:
1
Article number:
187
Publication date:
2021-02-18
Acceptance date:
2021-01-22
DOI:
EISSN:
1471-2334
Pmid:
33602152

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